Increase in the number of cells as a result of cell division

The use of chemical agents in the treatment or control of disease or mental disorders

Medical research studies conducted on human subjects to answer scientific questions and to find better ways to prevent, detect or treat diseases

The ability of a drug to control or cure an illness or disease

Food and Drug Administration

Incorporation of a drug into a relevant delivery vehicle, such as a gel

Good Manufacturing Process

Situated within, performed within, occurring within, or administered by entering a vein - injection of a drug into the bloodstream through a vein

Situated or occurring within a body cavity (i.e. treatment characterized by the insertion of substances in a cavity)

Investigational new drug

An enzyme that catalyzes the transfer of phosphate groups from a high-energy phosphate-containing molecule (as ATP or ADP) to a substrate

Cancerous - of unfavorable prognosis

An epidermal cell that produces melanin

Transfer of a disease-producing agency (e.g. cancer cells) from an original site of disease to another part of the body with development of a similar lesion in a new location

A relatively permanent change in hereditary material (gene) involving a physical change in chromosome relations

A system of proteins that work together

The study of the bodily absorption, distribution, metabolism and excretion of drugs

Evaluation of the activity of the drug in various cell systems and animal models of the disease

Clinical trial designed to determine the safety and appropriate dose

Clinical trial designed to measure the safety and efficacy

Clinical trial designed to test new treatment and measure efficacy as well as safety as compared to the standard of care

A trend or shift toward a high, more severe state - increase of tumour size (opposite of regression)

A chemical group or molecule (as a protein) on the cell surface or in the cell interior that has an affinity for a specific chemical group, molecule, or virus

A systematic plan designed to improve and maintain the health of a patient

A trend or shift toward a lower, less severe or less perfect state - reduction in the size of tumour (opposite of progression)

Of or relating to the treatment of disease or disorders by remedial agents or methods

Treatment(s)

The quality, state, or relative degree of being toxic or poisonous

Evaluation of the safety profile of a drug

An abnormal benign or malignant mass of tissue that is not inflammatory, arises without obvious cause from cells of preexistent tissue, and possesses no physiological function