LEO Pharma's PEP005 Meets Primary Endpoint in Phase III Trial for Pre-Cancerous Skin Condition read more
Positive Results for LEO Pharma's Phase III Actinic Keratosis Trials on the Face and Scalp read more
LEO Pharma Completes Peplin Acquisition; Peplin to Continue as an Independent Subsidiary read more
Letter to our CDI Holders read more
We are developing a new class of naturally occurring compounds that we believe have the potential to treat certain skin cancers and pre-cancerous lesions, while addressing some of the limitations of existing treatment alternatives. These compounds are small molecules that we extract and purify from Euphorbia peplus, a rapidly growing, readily-available plant commonly referred to as petty spurge or radium weed. The sap of E. peplus has a long history of traditional use for a variety of conditions, and particularly topical self-treatment of various skin disorders, including skin cancer. We refer to our lead compound derived from E. peplus as PEP005 (ingenol mebutate), or PEP005.
In our preclinical studies for PEP005, we have observed that the topical application of PEP005 has two distinct and complementary mechanisms of action.
Our lead product candidate, currently in Phase 3 clinical trials, is a patient-applied topical gel for the treatment of AK. We are also developing a topical gel for the treatment of superficial BCC. We also intend to evaluate the utility of PEP005 in a topical formulation for treating other skin disorders, including nodular BCC, SCC and cutaneous warts.
