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Publications
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The anti-tumor agent, ingenol-3-angelate (PEP005), promotes the recruitment of cytotoxic neutrophils by activation of vascular endothelial cells in a PKC-delta dependent manner
Hampson P, Kavanagh D, Smith E, Wang K, Lord JM, Ed Rainger G
Cancer Immunol Immunother., 2008 Feb 12 (Epub ahead of print)
PMID: 18265980 [PubMed - as supplied by publisher]
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Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate
Challacombe JM, Suhrbier A, Parsons PG, Jones B, Hampson P, Kavanagh D, Rainger GE, Morris M, Lord JM, Le TT, Hoang-Le D, Ogbourne SM
J Immunology, 2006 Dec 1, 177(11): 8123-8132
PMID: 17114407 [PubMed - in process]
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Induction of senescence in diterpene ester-treated melanoma cells via protein kinse C-dependent hyperactivation of the mitogen-activated protein kinsae pathway
Cozzi SJ, Parsons PG, Ogbourne SM, Pedley J, Boyle GM
Cancer Res., 2006 Oct 15; 66(20): 10083-10091
PMID: 17047072 (PubMed - in process)
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PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC
Hampson P, Chahal H, Khanim F, Hayden R, Mulder A, Assi LK, Bunce CM, Lord JM
Blood, 2005 Aug 15; 106(4): 1362-1358 (Epub 2005 Apr 21)
PMID: 15845901 (PubMed - indexed for MEDLINE]
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Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells
Gillespie SK, Zhang XD, Hersey P
Mol Cancer Ther., 2004 Dec; 3(12): 1651-1658
PMID: 15634659 [Pub Med - indexed for MEDLINE]
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Characterization of the interaction of ingenol 3-angelate with protein kinase C
Kedei N, Lundberg DJ, Toth A, Welburn P, Garfield SH, Blumberg PM
Cancer Res, 2004 May 1; 64: 3243-3255
PMID: 15923197 [Pub Med - indexed for MEDLINE]
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Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death
Ogbourne SM, Suhrbier A, Jones B, Cozzi SJ, Boyle GM, Morris M, McAlpine D, Johns J, Scott TM, Sutherland KP, Gardner JM, Le TT, Lenarczyk A, Aylward JH, Parsons PG
Cancer Res., 2004 Apr 15; 64(8): 2833-39
PMID: 15087400 [Pub Med - indexed for MEDLINE]
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